• The protein encoded by this gene is a transcription factor that contains two GATA-type zinc fingers. The encoded protein is known to bind to hepatocyte nuclear factor-1alpha (HNF-1alpha), and this interaction is essential for cooperative activation of the intestinal lactase-phlorizin hydrolase promoter. In other organisms, similar proteins may be involved in the establishment of cardiac smooth muscle cell diversity. [provided by RefSeq, Jul 2008]

GATA5 (GATA Binding Protein 5) is a Protein Coding gene. Diseases associated with GATA5ne Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and transcription cis-regulatory region binding. An important paralog of this gene 

• Transcription factor required during cardiovascular development  an important role in the transcriptional program(s) that underlies smooth muscle cell diversity (By similarity). Binds to the functionally important CEF-1 nuclear protein binding site in the cardiac-specific slow/cardiac troponin C transcriptional enhancer.